This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
NOD2 Protein Homology
The following homologs of human NOD2 were found using HomoloGene and BLAST.
Organism: Mus musculus (Mouse)
Abbreviation: Nod2 Protein Accession #: NP_665856.2 Protein Sequence: FASTA Identity (%): 79.3 Organism: Canus lupus familiaris (Dog) Abbreviation: NOD2 Protein Accession #: XP_544412.3* Protein Sequence: FASTA Identity (%): 83.4 Organism: Rattus norvegicus (Rat) Abbreviation: Nod2 Protein Accession #: NP_001099642.1 Protein Sequence: FASTA Identity (%): 80.0 Organism: Danio rerio (Zebrafish) Abbreviation: nod2 Protein Accession #: XP_697924.3* Protein Sequence: FASTA Identity (%): 49.8 |
Organism: Macaca mulatta (Rhesus Macaque)
Abbreviation: NOD2 Protein Accession #: XP_001084287.1* Protein Sequence: FASTA Identity (%): 95.6 Organism: Bos taurus (Cow) Abbreviation: NOD2 Protein Accession #: NP_001002889.1 Protein Sequence: FASTA Identity (%): 81.2 Organism: Pan troglodytes(Chimpanzee) Abbreviation: NOD2 Protein Accession #: NP_001098710.1 Protein Sequence: FASTA Identity (%): 99.1 |
Analysis
As we saw in the gene homology section, NOD2 only has a limited number of homologs compared to other human proteins, limiting our model organisms mainly to mice and zebrafish. The lack of NOD2 in
C. elegans, Drosophila melanogaster, or A. thaliana restricts our studies but is also worth note in that it implies that NOD2 is present only in vertebrates.