This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
NOD2 Gene Homology
The following homologs of human NOD2 were found using HomoloGene and BLAST.
Organism: Mus musculus (Mouse)
Abbreviation: Nod2 Gene Accession #: NC_000074.5 Gene Sequence: FASTA Identity (%): 80.8 Organism: Canus lupus familiaris (Dog) Abbreviation: NOD2 Gene Accession #: XM_544412.3* Gene Sequence: FASTA Identity (%): 85.4 Organism: Rattus norvegicus (Rat) Abbreviation: Nod2 Gene Accession #: NC_005118.2 Gene Sequence: FASTA Identity (%): 80.7 Organism: Danio rerio (Zebrafish) Abbreviation: nod2 Gene Accession #: NC_007118.5 Gene Sequence: FASTA Identity (%): 54.0 |
Organism: Macaca mulatta (Rhesus Macaque)
Abbreviation: NOD2 Gene Accession #: XM_001084287.2* Gene Sequence: FASTA Identity (%): 96.0 Organism: Bos taurus (Cow) Abbreviation: NOD2 Gene Accession #: AC_000175.1 Gene Sequence: FASTA Identity (%): 83.5 Organism: Pan troglodytes(Chimpanzee) Abbreviation: NOD2 Gene Accession #: NC_006483.3 Gene Sequence: FASTA Identity (%): 99.2 |
*Note that accession numbers beginning with an "X" denote predicted sequences
Analysis
The number of NOD2 homologs in common model organisms is limited compared to other human genes. For example, homologs were not found in the common model organisms C. elegans, Drosophila melanogaster, or A. thaliana. The fact that homologs were found only in vertebrates is of interest. Though BLASTing the organisms whose genomes have been sampled is not an exhaustive sampling, the absence of other NOD2 homologs suggests that the gene may be exclusive to vertebrates.